The multi-physical field coupling experimental environment for high temperature liquid lead bismuth eutectic and high pressure helium heat transfer has been realized by the experimental setup, which can provide experiment and verification platform for thermal-hydraulic study of advanced second-loop cooling system of ADS (Accelerator Driven Sub-critical System). The LBE loop temperature is 500℃, the LBE flow rate is 0.5m/s, the helium loop operating pressure is 3.4MPa, the helium mass flow rate is 0.12kg/s, and the total heat exchange in the system is designed to 30kW.